Casale put his famous Hollywood studio/home on the market for $4.995 million, according to property records.
The Ohio native has moved full-time to a ranch in Napa, California, where he focuses on marketing grape fruit.
Casale's Los Angeles compound has been the site of many famous audio and video productions.
The place was originally built in 1962 and is located in the heart of Hollywood. The ground floor is a state-of-the-art music studio and the first floor is a modern private residence.
The 6,800-square-foot lot is surrounded by high walls and enclosed by security gates that lead to a six-car car park for guests or clients.
The ground floor entrance of the 4,900 square foot building features a lobby that leads to an elaborate recording studio and state-of-the-art control room. It is equipped with everything a modern recording engineer needs.
Upstairs, the open-plan Great Room comprises a living room, dining area and modern kitchen. There is also an office, bedroom, laundry room and three bathrooms.
Outdoor spaces include a patio with a tranquil koi pond.
In the early 1970s, Casale founded the band Devo with his brothers Bob Casale, Mark Mothersbaugh and Bob Mothersbaugh. He is probably best known for "Whip It."
He has also had a successful solo career and has produced hit music videos for Devo and other groups.
Casale's interest in wine has also been long-standing since he moved to California more than 40 years ago. He is involved in many aspects of the winemaking and marketing process.
Qualified buyers who schedule a showing will meet with the owner to learn about the property's wide range of residential and recording features, said Max Shapiro, listing agent with Westside Estate Agency.